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Stimulus‐secretion coupling by high‐affinity IgE receptor: New developments
Author(s) -
Benhamou Marc,
Blank Ulrich
Publication year - 2010
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2010.09.023
Subject(s) - stimulus (psychology) , receptor , secretion , chemistry , immunoglobulin e , neuroscience , biophysics , biology , biochemistry , psychology , immunology , antibody , cognitive psychology
Stimulation of mast cells through their high affinity IgE receptor (FcεRI) leads to the secretion of pre‐ and neoformed soluble mediators through vesicular carriers. This process is highly regulated in order to adapt the secretion of these potentially dangerous factors to the physiological needs. This regulation requires numerous essential effectors that are necessary to transmit the initial signal of FcεRI aggregation and couple it to the sophisticated secretory machinery of membrane fusion. Studies in recent years have led to the discovery of a series of new effector molecules that link FcεRI to secretion. We describe here some of the new developments that have allowed to obtain a clearer picture of stimulus/secretion coupling in mast cells.