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Multiple pathways leading from the T‐cell antigen receptor to the actin cytoskeleton network
Author(s) -
Reicher Barak,
Barda-Saad Mira
Publication year - 2010
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2010.09.002
Subject(s) - microbiology and biotechnology , t cell receptor , actin remodeling , actin cytoskeleton , cytoskeleton , effector , actin , signal transduction , biology , actin remodeling of neurons , immunological synapse , profilin , intracellular , t cell , chemistry , cell , immunology , immune system , biochemistry
Dynamic rearrangements of the actin cytoskeleton, following T‐cell antigen receptor (TCR) engagement, provide the structural matrix and flexibility to enable intracellular signal transduction, cellular and subcellular remodeling, and driving effector functions. Recently developed cutting‐edge imaging technologies have facilitated the study of TCR signaling and its role in actin‐dependent processes. In this review, we describe how TCR signaling cascades induce the activation of actin regulatory proteins and the formation of actin networks, and how actin dynamics is important for T‐cell homeostasis, activation, migration, and other effector functions.