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Cytoskeletal cross‐talk in the control of T cell antigen receptor signaling
Author(s) -
Lasserre Rémi,
Alcover Andrés
Publication year - 2010
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2010.09.001
Subject(s) - immunological synapse , microbiology and biotechnology , cytoskeleton , actin cytoskeleton , biology , microtubule , signal transduction , actin , cell , t cell , t cell receptor , immunology , immune system , biochemistry
T cell antigen receptor signaling is triggered and controlled in specialized cellular interfaces formed between T cells and antigen‐presenting cells named immunological synapses. Both microtubules and actin cytoskeleton rearrange at the immunological synapse in response to T cell receptor triggering, ensuring in turn the accuracy of intracellular signaling. Recent reports show that the cross‐talk between the cortical actin cytoskeleton and microtubule networks is key for structuring the immunological synapse and for controlling T cell receptor signaling. Immunological synapse architecture and the interaction between the signaling machinery and various cytoskeletal elements are therefore crucial for the fine‐tuning of T cell signaling.