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MicroRNA‐24 targeting RNA‐binding protein DND1 in tongue squamous cell carcinoma
Author(s) -
Liu Xiqiang,
Wang Anxun,
Heidbreder Caroline E.,
Jiang Lu,
Yu Jinsheng,
Kolokythas Antonia,
Huang Lei,
Dai Yang,
Zhou Xiaofeng
Publication year - 2010
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2010.08.040
Subject(s) - microrna , gene knockdown , carcinogenesis , messenger rna , biology , microbiology and biotechnology , cancer research , apoptosis , chemistry , gene , biochemistry
Deregulations of microRNA have been frequently observed in tongue squamous cell carcinoma (TSCC), but their roles in tumorigenesis are not entirely clear. Here, we reported the up‐regulation of miR‐24 in TSCC. MiR‐24 up‐regulation reduced the expression of RNA‐binding protein dead end 1 (DND1). Knockdown of miR‐24 led to enhanced expression of DND1. The direct targeting of miR‐24 to the DND1 mRNA was predicted bioinformatically and confirmed by luciferase reporter gene assays. Furthermore, the miR‐24‐mediated change in DND1 expression suppressed the expression of cyclin‐dependent kinase inhibitor 1B (CDKN1B), and also led to enhanced proliferation and reduced apoptosis in TSCC cells.