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Receptors and signaling mechanisms for B‐lymphocyte activation, proliferation and differentiation – Insights from both in vivo and in vitro approaches
Author(s) -
Maddaly Ravi,
Pai Govind,
Balaji Shruti,
Sivaramakrishnan Priya,
Srinivasan Lakshmi,
Sunder Sukanya Shyama,
Paul Solomon F.D.
Publication year - 2010
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2010.08.022
Subject(s) - microbiology and biotechnology , signal transduction , biology , in vivo , cellular differentiation , receptor , in vitro , b cell , immunology , biochemistry , genetics , antibody , gene
During the last three decades, a number of B‐lymphocyte specific surface antigens have been defined some of which may also show activation/differentiation specific expression. Here, we review the various signaling events and the receptor‐ligand interactions for B‐cell development, activation and differentiation. Our discussion and presentation include reviewing the in vivo and in vitro mechanisms. Focus is on the experiments that give us valuable insights into the B cell signaling mechanisms in vitro. Three significant pathways in B‐cell development – c‐Kit, FLT‐3 and IL‐7 signaling pathways are elucidated upon. Both antigen dependent and antigen independent mechanisms of B cell stimulation are also reviewed.