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A distinct subset of podoplanin (gp38) expressing F4/80+ macrophages mediate phagocytosis and are induced following zymosan peritonitis
Author(s) -
Hou Tie Zheng,
Bystrom Jonas,
Sherlock Jonathan P.,
Qureshi Omar,
Parnell Sonia M.,
Anderson Graham,
Gilroy Derek W.,
Buckley Christopher D.
Publication year - 2010
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2010.07.053
Subject(s) - podoplanin , phagocytosis , zymosan , peritonitis , macrophage , peritoneal cavity , peritoneum , in vitro , stromal cell , inflammation , immunology , in vivo , opsonin , microbiology and biotechnology , chemistry , biology , medicine , lymphatic system , cancer research , pathology , biochemistry , anatomy , genetics
Macrophages are important tissue resident cells that regulate the dynamics of inflammation. However, they are strikingly heterogeneous. During studies looking at podoplanin (gp38) expression on stromal cells in the murine spleen and peritoneal cavity we unexpectedly discovered that podoplanin was expressed on a subset of F4/80 + macrophages; a subset which we have termed fibroblastic macrophages (FM). These cells function as phagocytes in vitro as measured by bead mediated phagocytosis assays. FM also exist at high frequency in the peritoneal cavity and in zymosan induced peritonitis in vivo. These FM represent a unique subgroup of F4/80 + macrophages and their presence in the inflamed peritoneum suggests that they play a role in zymosan induced peritonitis.