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The MRN complex in double‐strand break repair and telomere maintenance
Author(s) -
Lamarche Brandon J.,
Orazio Nicole I.,
Weitzman Matthew D.
Publication year - 2010
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2010.07.029
Subject(s) - telomere , homologous recombination , rad50 , dna repair , dna , homologous chromosome , biology , dna damage , microbiology and biotechnology , non homologous end joining , genetics , computational biology , dna binding protein , gene , transcription factor
Genomes are subject to constant threat by damaging agents that generate DNA double‐strand breaks (DSBs). The ends of linear chromosomes need to be protected from DNA damage recognition and end‐joining, and this is achieved through protein–DNA complexes known as telomeres. The Mre11–Rad50–Nbs1 (MRN) complex plays important roles in detection and signaling of DSBs, as well as the repair pathways of homologous recombination (HR) and non‐homologous end‐joining (NHEJ). In addition, MRN associates with telomeres and contributes to their maintenance. Here, we provide an overview of MRN functions at DSBs, and examine its roles in telomere maintenance and dysfunction.