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TFPI or uPA–PAI‐1 complex affect cell function through expression variation of type II very low density lipoprotein receptor
Author(s) -
Di Yong,
Liu Zhiguo,
Tian Jun,
Zong Yiqiang,
Yang Pu,
Qu Shen
Publication year - 2010
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2010.07.005
Subject(s) - chemistry , plasminogen activator , extracellular , plasminogen activator inhibitor 1 , urokinase receptor , receptor , cell growth , microbiology and biotechnology , endocrinology , medicine , biology , biochemistry
Very low density lipoprotein receptors (VLDLR) including type I and type II are known to affect cell functions by binding to its extracellular ligands. However, the effect of these ligands on VLDLR expression remains elusive. Tissue factor pathway inhibitor (TFPI) and urokinase plasminogen activator and plasminogen activator inhibitor 1 (uPA–PAI‐1) complex, two ligands of VLDLR, were used to examine their effects on VLDLR expression. TFPI treatment decreased type II VLDLR expression, inhibited cell proliferation and migration, and degradated β‐catenin in SGC7901 cells. However, uPA–PAI‐1 complex, increased type II VLDLR expression with promoted cell proliferation and migration and stabilization of β‐catenin. These results indicated that extracellular ligands can change the expression of type II VLDLR to affect cell proliferation and migration.