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Brown vs white adipocytes: The PPARγ coregulator story
Author(s) -
Koppen Arjen,
Kalkhoven Eric
Publication year - 2010
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2010.06.035
Subject(s) - adipogenesis , adipose tissue , white adipose tissue , adipocyte , medicine , endocrinology , brown adipose tissue , transcription factor , biology , adipose tissue macrophages , peroxisome proliferator activated receptor , microbiology and biotechnology , receptor , genetics , gene
The development of adipose tissue is a process which involves the concerted cooperation of numerous transcription factors together with their coactivators and corepressors. The peroxisome proliferator‐activated receptor γ (PPARγ) is considered to be one of the master regulators of adipocyte differentiation. The presence of two functionally distinct types of adipose tissue, white and brown (WAT and BAT), requires an even more complex regulation of adipose tissue development. In this review we will focus on the role of PPARγ coregulators in adipogenesis and especially on the role of PPARγ coregulators in white and brown adipose tissue. Specificity in coregulator function in WAT and BAT may form an additional level of regulation of adipose tissue development.