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Neurotrophic peptides incorporating adamantane improve learning and memory, promote neurogenesis and synaptic plasticity in mice
Author(s) -
Li Bin,
Wanka Lukas,
Blanchard Julie,
Liu Fei,
Chohan Muhammad Omar,
Iqbal Khalid,
Grundke-Iqbal Inge
Publication year - 2010
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2010.06.025
Subject(s) - neurogenesis , dentate gyrus , neuroscience , subgranular zone , neurotrophin , neurotrophic factors , synaptic plasticity , neuroplasticity , hippocampus , brain derived neurotrophic factor , psychology , neural stem cell , biology , microbiology and biotechnology , stem cell , subventricular zone , receptor , biochemistry
Development of neurotrophic peptidergic drugs that can mimic neurotrophins and promote neurogenesis and maturation of newborn cells into mature functional neurons represents an exciting therapeutic opportunity for treatment of Alzheimer disease and other learning and memory disorders as well as enhancing cognition of normal individuals. Here we report the design of a peptidergic compound, Ac‐DGGL A G‐NH 2 , called P21, when administered peripherally, enhanced learning as well as both short‐term and spatial reference memories of normal adult C57Bl6 mice. P21 induced enhancement of neurogenesis and maturation of newly born neurons in the granular cell layer and subgranular zone of the dentate gyrus.