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Retracted: Modulation of hypothalamic PTP1B in the TNF‐α‐induced insulin and leptin resistance
Author(s) -
Picardi Paty Karoll,
Caricilli Andrea Moro,
de Abreu Lélia Lelis Ferreira,
Carvalheira José Barreto Campello,
Velloso Lício Augusto,
Saad Mário José Abdalla
Publication year - 2010
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2010.05.064
Subject(s) - leptin , medicine , endocrinology , insulin resistance , insulin , hypothalamus , tumor necrosis factor alpha , insulin receptor , leptin receptor , obesity
We have associated functional and molecular studies of insulin and leptin to investigate the effect of TNF‐α on central insulin and leptin signaling in rats pre‐treated with PTP1B‐ASO. The icv infusion of TNF‐α‐induced an increase in PTP1B protein expression and activity, and attenuated insulin and leptin sensitivity and signaling in the hypothalamus. However, TNF‐α was able to completely blunt the leptin and insulin effect in rats treated with PTP1B‐ASO, suggesting that TNF‐α does not require PTP1B to fully attenuate the leptin and insulin effects. In addition, our data also show that other mechanisms of insulin and leptin resistance are activated in the hypothalamus by TNF‐α.