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Metabolism of postsynaptic recombination intermediates
Author(s) -
Adelman Carrie A.,
Boulton Simon J.
Publication year - 2010
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2010.05.023
Subject(s) - rad51 , homologous recombination , replication protein a , dna repair , biology , microbiology and biotechnology , dna , dna damage , caenorhabditis elegans , postreplication repair , homologous chromosome , dna replication , genetics , chemistry , dna mismatch repair , gene , dna binding protein , transcription factor
DNA double strand breaks and blocked or collapsed DNA replication forks are potentially genotoxic lesions that can result in deletions, aneuploidy or cell death. Homologous recombination (HR) is an essential process employed during repair of these forms of damage. HR allows for accurate restoration of the damaged DNA through use of a homologous template for repair. Although inroads have been made towards understanding the mechanisms of HR, ambiguity still surrounds aspects of the process. Until recently, relatively little was known concerning metabolism of postsynaptic RAD51 filaments or how synthesis dependent strand annealing intermediates are processed. This review discusses recent findings implicating RTEL1, HELQ and the Caenorhabditis elegans RAD51 paralog RFS‐1 in post‐strand exchange events during HR.