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Epigallocatechin‐3‐gallate protects motor neurons and regulates glutamate level
Author(s) -
Yu Jixu,
Jia Yaqiong,
Guo Yansu,
Chang Geng,
Duan Weisong,
Sun Mengmeng,
Li Bin,
Li Chunyan
Publication year - 2010
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2010.05.011
Subject(s) - excitotoxicity , neuroprotection , glutamate receptor , chemistry , gallate , pharmacology , epigallocatechin gallate , biochemistry , antioxidant , polyphenol , microbiology and biotechnology , biology , receptor
Epigallocatechin‐3‐gallate (EGCG) is a major component of green tea polyphenols which displays potential properties of anticancer and neuroprotection. Here we show that protection of motor neuron by EGCG is associated with regulating glutamate level in organotypic culture of rat spinal cord. In this model, EGCG blocked glutamate excitotoxicity caused by threohydroxyaspartate, an inhibitor of glutamate transporter. This property of EGCG may be not due to its intrinsic antioxidative activity, because another antioxidant could not regulate glutamate level under the same condition. These results show that EGCG may be a potential therapeutic candidate for neurodegenerative diseases involving glutamate excitotoxicity such as ALS.