Premium
Insulin‐degrading enzyme antagonizes insulin‐dependent tissue growth and Aβ‐induced neurotoxicity in Drosophila
Author(s) -
Tsuda Manabu,
Kobayashi Toshikazu,
Matsuo Takashi,
Aigaki Toshiro
Publication year - 2010
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2010.05.010
Subject(s) - insulin degrading enzyme , neurotoxicity , insulin , pathogenesis , mutant , insulin receptor , biology , drosophila (subgenus) , enzyme , mutation , microbiology and biotechnology , drosophila melanogaster , carbohydrate metabolism , biochemistry , gene , insulin resistance , endocrinology , medicine , toxicity , immunology
Insulin‐degrading enzyme (IDE) is implicated in the pathogenesis of type 2 diabetes mellitus (DM2) and Alzheimer's disease (AD). Here we provide genetic evidence that Drosophila Ide ( dIde ) antagonizes the insulin signaling pathway and human Aβ‐induced neurotoxicity in Drosophila . In this study, we also generated a dIde knockout mutant ( dIde KO ) by gene targeting, and found that loss of IDE increases the content of the major insect blood sugar, trehalose, thus suggesting a conserved role of IDE in sugar metabolism. Using dIde KO as a model, further investigations into the biological functions of IDE and its role in the pathogenesis of DM2 and AD can be made.