z-logo
Premium
Insulin‐degrading enzyme antagonizes insulin‐dependent tissue growth and Aβ‐induced neurotoxicity in Drosophila
Author(s) -
Tsuda Manabu,
Kobayashi Toshikazu,
Matsuo Takashi,
Aigaki Toshiro
Publication year - 2010
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2010.05.010
Subject(s) - insulin degrading enzyme , neurotoxicity , insulin , pathogenesis , mutant , insulin receptor , biology , drosophila (subgenus) , enzyme , mutation , microbiology and biotechnology , drosophila melanogaster , carbohydrate metabolism , biochemistry , gene , insulin resistance , endocrinology , medicine , toxicity , immunology
Insulin‐degrading enzyme (IDE) is implicated in the pathogenesis of type 2 diabetes mellitus (DM2) and Alzheimer's disease (AD). Here we provide genetic evidence that Drosophila Ide ( dIde ) antagonizes the insulin signaling pathway and human Aβ‐induced neurotoxicity in Drosophila . In this study, we also generated a dIde knockout mutant ( dIde KO ) by gene targeting, and found that loss of IDE increases the content of the major insect blood sugar, trehalose, thus suggesting a conserved role of IDE in sugar metabolism. Using dIde KO as a model, further investigations into the biological functions of IDE and its role in the pathogenesis of DM2 and AD can be made.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here