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Evidence for a positive role of PtdIns5P in T‐cell signal transduction pathways
Author(s) -
Guittard Geoffrey,
Mortier Eva,
Tronchère Hélène,
Firaguay Guylène,
Gérard Audrey,
Zimmermann Pascale,
Payrastre Bernard,
Nunès Jacques A.
Publication year - 2010
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2010.04.051
Subject(s) - microbiology and biotechnology , signal transduction , second messenger system , phosphatase , mapk/erk pathway , phosphatidylinositol , protein kinase b , t cell , t cell receptor , kinase , biology , cell growth , chemistry , phosphorylation , biochemistry , immunology , immune system
Phosphatidylinositol 5‐phosphate (PtdIns5P) is emerging as a potential lipid messenger involved in several cell types, from plants to mammals. Expression of IpgD, a PtdIns(4, 5)P 2 4‐phosphatase induces Src kinase and Akt, but not ERK activation and enhances interleukin II promoter activity in T‐cells. Expression of a new PtdIns5P interacting domain blocks IpgD‐induced T‐cell activation and selective signaling molecules downstream of TCR triggering. Altogether, these data suggest that PtdIns5P may play a sensor function in setting the threshold of T‐cell activation and contributing to maintain T‐cell homeostasis.