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Endoplasmic reticulum stress response is involved in Mycobacterium tuberculosis protein ESAT‐6‐mediated apoptosis
Author(s) -
Choi Hong-Hee,
Shin Dong-Min,
Kang Gun,
Kim Ki-Hye,
Park Jin Bong,
Hur Gang Min,
Lee Hye-Mi,
Lim Yun-Ji,
Park Jeong-Kyu,
Jo Eun-Kyeong,
Song Chang-Hwa
Publication year - 2010
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2010.04.050
Subject(s) - endoplasmic reticulum , esat 6 , apoptosis , unfolded protein response , microbiology and biotechnology , mycobacterium tuberculosis , chemistry , tuberculosis , biology , medicine , pathology , biochemistry
Mycobacterium tuberculosis (Mtb) infection leads to the induction of the apoptotic response, which is associated with bacilli killing. The early secreted mycobacterial antigen ESAT‐6 of Mtb has been shown to induce apoptosis in human macrophages and epithelial cells. In the present study, we demonstrate that the stimulation of human epithelial A549 cells by ESAT‐6 induces the endoplasmic reticulum (ER) stress response. We observed that ESAT‐6 treatment increases intracellular Ca 2+ concentration, which results in ROS accumulation, and therefore induces the onset of ER stress‐induced apoptosis. Our results uncover a novel apoptotic mechanism of ESAT‐6 through ER stress responses in pathologic conditions such as tuberculosis.