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A structural classification of substrate‐binding proteins
Author(s) -
Berntsson Ronnie P.-A.,
Smits Sander H.J.,
Schmitt Lutz,
Slotboom Dirk-Jan,
Poolman Bert
Publication year - 2010
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2010.04.043
Subject(s) - protein data bank (rcsb pdb) , protein data bank , transporter , dna binding protein , biochemistry , structural biology , plasma protein binding , structural bioinformatics , protein structure , computational biology , substrate (aquarium) , substrate specificity , chemistry , biology , transcription factor , enzyme , gene , ecology
Substrate‐binding proteins (SBP) are associated with a wide variety of protein complexes. The proteins are part of ATP‐binding cassette transporters for substrate uptake, ion gradient driven transporters, DNA‐binding proteins, as well as channels and receptors from both pro‐ and eukaryotes. A wealth of structural and functional data is available on SBPs, with over 120 unique entries in the Protein Data Bank (PDB). Over a decade ago these proteins were divided into three structural classes, but based on the currently available wealth of structural data, we propose a new classification into six clusters, based on features of their three‐dimensional structure.