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Lipid outward translocation by ABC proteins
Author(s) -
Nagao Kohjiro,
Kimura Yasuhisa,
Mastuo Michinori,
Ueda Kazumitsu
Publication year - 2010
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2010.04.036
Subject(s) - atp binding cassette transporter , microbiology and biotechnology , chromosomal translocation , membrane protein , biology , bacterial outer membrane , transport protein , chemistry , biochemistry , membrane , gene , escherichia coli , transporter
In humans, about 50 ABC proteins play physiologically important roles. Many ABC proteins are involved in lipid outward translocation and lipid homeostasis in the body, and defects in their functions cause various diseases. However, the precise mechanisms of substrate transport remain unclear. In bacteria, several ABC proteins are involved in the transport of lipoproteins and lipopolysaccharides from the inner to outer membrane, and their functioning is a prerequisite for survival. Their functions can be divided into “flip‐flop” and “projection”. In this review, human ABC proteins are compared to bacterial proteins to elucidate their mechanisms.