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Mitochondrial calcium channels
Author(s) -
Hoppe Uta C.
Publication year - 2010
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2010.04.017
Subject(s) - uniporter , ryanodine receptor , microbiology and biotechnology , mitochondrion , chemistry , biophysics , calcium , transporter , calcium signaling , biology , biochemistry , signal transduction , cytosol , gene , endoplasmic reticulum , organic chemistry , enzyme
Mitochondrial Ca 2+ handling plays an important role in energy production and various cellular signaling processes. Mitochondrial Ca 2+ uptake is regulated by the mitochondrial Ca 2+ uniporter (MCU), at least one non‐MCU Ca 2+ channel and possibly a mitochondrial ryanodine receptor. Two distinct mechanisms mediate Ca 2+ outward transport, the Na + ‐dependent (mNCX) and the Na + ‐independent Ca 2+ efflux. In recent years we gained more insight into the regulation and function of these different Ca 2+ transport mechanisms. However, the precise physiological role and the molecular structure of all mitochondrial Ca 2+ transporters and channels still has to be determined.