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Tricks of the trade used to accelerate high‐resolution structure determination of membrane proteins
Author(s) -
Sonoda Yo,
Cameron Alex,
Newstead Simon,
Omote Hiroshi,
Moriyama Yoshinori,
Kasahara Michihiro,
Iwata So,
Drew David
Publication year - 2010
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2010.04.015
Subject(s) - membrane protein , membrane , high resolution , chemistry , computational biology , biophysics , biology , biochemistry , geography , remote sensing
The rate at which X‐ray structures of membrane proteins are solved is on a par with that of soluble proteins in the late 1970s. There are still many obstacles facing the membrane protein structural community. Recently, there have been several technical achievements in the field that have started to dramatically accelerate structural studies. Here, we summarize these so‐called ‘tricks‐of‐the‐trade’ and include case studies of several mammalian transporters.