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Folded‐unfolded cross‐predictions and protein evolution: The case study of coiled‐coils
Author(s) -
Szappanos Balázs,
Süveges Dániel,
Nyitray László,
Perczel András,
Gáspári Zoltán
Publication year - 2010
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2010.03.026
Subject(s) - coiled coil , sequence (biology) , electromagnetic coil , protein structure prediction , obligate , computational biology , protein structure , biophysics , biological system , computer science , biology , physics , nuclear magnetic resonance , genetics , ecology , quantum mechanics
Here we report a thorough analysis of cross‐predictions between coiled‐coil and disordered protein segments using various prediction algorithms for both sequence classes. Coiled‐coils are often predicted to be unstructured, consistent with their obligate multimeric nature, whereas reverse cross‐predictions are rare due to the regularity of coiled‐coil sequences. We propose the simultaneous use of the programs C oils and IUP red to achieve acceptable prediction accuracy and minimize the extent of cross‐predictions. The relevance of observed cross‐predictions might be that disordered sequences can adopt coiled‐coil conformation relatively easily during protein evolution.