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Lipid droplets: A dynamic organelle moves into focus
Author(s) -
Beller Mathias,
Thiel Katharina,
Thul Peter J.,
Jäckle Herbert
Publication year - 2010
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2010.03.022
Subject(s) - organelle , endoplasmic reticulum , lipid droplet , peroxisome , proteome , microbiology and biotechnology , membrane contact site , mitochondrion , biology , chemistry , biochemistry , membrane protein , integral membrane protein , membrane , gene
Lipid droplets (LDs) were perceived as static storage deposits, which passively participate in the energy homeostasis of both cells and entire organisms. However, this view has changed recently after the realization of a complex and highly dynamic LD proteome. The proteome contains key components of the fat mobilization system and proteins that suggest LD interactions with a variety of cell organelles, including the endoplasmic reticulum, mitochondria and peroxisomes. The study of LD cell biology, including cross‐talk with other organelles, the trafficking of LDs in the cell and regulatory events involving the LD coat proteins is now on the verge of leaving its infancy and unfolds that LDs are highly dynamic cellular organelles.