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Altered circadian rhythm of the clock genes in fibrotic livers induced by carbon tetrachloride
Author(s) -
Chen Peng,
Kakan Xiamusiya,
Zhang Jianfa
Publication year - 2010
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2010.03.019
Subject(s) - circadian rhythm , medicine , endocrinology , clock , biology , circadian clock , cryptochrome , rhythm , fibrosis , carbon tetrachloride , chemistry , organic chemistry
Disruption in circadian rhythms either by mutation in mice or by shiftwork in people, is associated with an increased risk for the development of multiple organ diseases. In turn, organ disease may influence the function of clock genes and peripheral circadian systems. Here we showed that hepatic fibrosis induced by carbon tetrachloride in mice leads to alterations in the circadian rhythms of hepatic clock genes. Especially, we found an impaired daily Cry2 rhythm in the fibrotic livers, with markedly decreased levels during the day time while compared with control livers. Associatively, the expressions of two important clock‐regulated genes peroxisome proliferator‐activated receptor alpha and cytochrome P450 oxidoreductase lost circadian rhythm with significantly decreased levels during the light–dark (12/12 h) cycle in fibrotic livers.