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Circadian clock control of the cellular response to DNA damage
Author(s) -
Sancar Aziz,
Lindsey-Boltz Laura A.,
Kang Tae-Hong,
Reardon Joyce T.,
Lee Jin Hyup,
Ozturk Nuri
Publication year - 2010
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2010.03.017
Subject(s) - cryptochrome , circadian clock , biology , circadian rhythm , microbiology and biotechnology , dna damage , period (music) , dna repair , clock , transcription (linguistics) , genetics , gene , dna , neuroscience , linguistics , physics , philosophy , acoustics
Mammalian cells possess a cell‐autonomous molecular clock which controls the timing of many biochemical reactions and hence the cellular response to environmental stimuli including genotoxic stress. The clock consists of an autoregulatory transcription–translation feedback loop made up of four genes/proteins, BMal1, Clock, Cryptochrome, and Period. The circadian clock has an intrinsic period of about 24 h, and it dictates the rates of many biochemical reactions as a function of the time of the day. Recently, it has become apparent that the circadian clock plays an important role in determining the strengths of cellular responses to DNA damage including repair, checkpoints, and apoptosis. These new insights are expected to guide development of novel mechanism‐based chemotherapeutic regimens.