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Identification of MyD88 as a novel target of miR‐155, involved in negative regulation of Helicobacter pylori ‐induced inflammation
Author(s) -
Tang Bin,
Xiao Bin,
Liu Zhen,
Li Na,
Zhu En-Dong,
Li Bo-Sheng,
Xie Qing-Hua,
Zhuang Yuan,
Zou Quan-Ming,
Mao Xu-Hu
Publication year - 2010
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2010.02.063
Subject(s) - inflammation , mir 155 , microrna , helicobacter pylori , signal transducing adaptor protein , regulator , biology , immune system , gene , microbiology and biotechnology , cancer research , immunology , signal transduction , genetics
MicroRNA‐155 (miR‐155) has been implicated as a central regulator of the immune system. We have previously reported that miR‐155 negatively regulates Helicobacter pylori ( H. pylori )‐induced inflammation, but the molecular mechanism of miR‐155 regulating the inflammation is not fully clear. Here, we identified myeloid differentiation protein 88 (MyD88) as a target gene of miR‐155, and found that miR‐155 decreased MyD88 expression at the protein but not the mRNA message level, suggesting that the miR‐155‐mediated inhibition is a post‐transcriptional event. Furthermore, the overexpression of miR‐155 led to significantly reduced IL‐8 production induced by H. pylori infection. Thus, we have demonstrated that miR‐155 can negatively regulate inflammation by targeting a key adaptor molecule MyD88 in inflammatory pathways.