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The protein encoded by the functional steroid receptor RNA activator is a new modulator of ER alpha transcriptional activity
Author(s) -
Chooniedass-Kothari Shilpa,
Vincett Daniel,
Yan Yi,
Cooper Charlton,
Hamedani Mohammad K.,
Myal Yvonne,
Leygue Etienne
Publication year - 2010
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2010.02.024
Subject(s) - activator (genetics) , rna , biology , estrogen receptor , receptor , microbiology and biotechnology , gene , steroid , estrogen receptor alpha , messenger rna , transcription (linguistics) , biochemistry , genetics , hormone , linguistics , philosophy , cancer , breast cancer
The steroid receptor RNA activator gene (SRA1) encodes for a functional RNA (SRA) as well as a protein (SRAP). While several groups reported on SRA‐RNA mechanism of action, SRAP exact function remains to be elucidated, mainly due to a lack of studies investigating the function of the protein independently of its RNA counterpart. Using two independent models to examine its specific functions, SRAP was found to enhance estrogen receptor alpha activity in a ligand and response‐element dependent manner. Our data therefore suggest that both transcript and protein products of the SRA1 gene co‐modulate the transcriptional activity of steroid receptors.