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Positive contribution of the IRE1α–XBP1 pathway to placental expression of CEA family genes
Author(s) -
Oikawa Daisuke,
Akai Ryoko,
Iwawaki Takao
Publication year - 2010
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2010.02.012
Subject(s) - xbp1 , biology , gene , transcription factor , placenta , genetics , rna splicing , rna , fetus , pregnancy
Inositol requiring enzyme‐1α (IRE1α) is an ER‐located transmembrane RNase whose activation leads to the production of the transcription factor X‐box binding protein 1 (XBP1). Recently, we showed that the IRE1α–XBP1 pathway plays an essential role in the placenta. However, details of its function remain unclear. To address this point, we searched for IRE1α‐ or XBP1‐regulated genes in the placenta, and identified the CEA family as a novel target of the IRE1α–XBP1 pathway. Moreover, PSG genes, which also belong to the CEA family, were up‐regulated by XBP1. We have therefore identified a new aspect of the physiological function of the IRE1α–XBP1 pathway in the placenta.