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Current knowledge of the pre‐autophagosomal structure (PAS)
Author(s) -
Suzuki Kuninori,
Ohsumi Yoshinori
Publication year - 2010
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2010.02.001
Subject(s) - autophagy , lytic cycle , vacuole , autophagosome , microbiology and biotechnology , saccharomyces cerevisiae , chemistry , biochemistry , biology , yeast , virology , apoptosis , cytoplasm , virus
Autophagy is a system for degradation of bulk cellular components in lytic compartments, vacuoles, or lysosomes when eukaryotic cells face with nutrient starvation. In this review, we focus on the pre‐autophagosomal structure (PAS), a functional entity responsible for autophagosome formation in Saccharomyces cerevisiae , and discuss its relevance to autophagy in mammalian cells.