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The intriguing links between prominin‐1 (CD133), cholesterol‐based membrane microdomains, remodeling of apical plasma membrane protrusions, extracellular membrane particles, and (neuro)epithelial cell differentiation
Author(s) -
Corbeil Denis,
Marzesco Anne-Marie,
Wilsch-Bräuninger Michaela,
Huttner Wieland B.
Publication year - 2010
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2010.01.050
Subject(s) - microbiology and biotechnology , lipid microdomain , extracellular , membrane , cell membrane , neuroepithelial cell , cell , chemistry , biology , stem cell , biochemistry , neural stem cell
Prominin‐1 (CD133) is a cholesterol‐interacting pentaspan membrane protein concentrated in plasma membrane protrusions. In epithelial cells, notably neuroepithelial stem cells, prominin‐1 is found in microvilli, the primary cilium and the midbody. These three types of apical membrane protrusions are subject to remodeling during (neuro)epithelial cell differentiation. The protrusion‐specific localization of prominin involves its association with a distinct cholesterol‐based membrane microdomain. Moreover, the three prominin‐1‐containing plasma membrane protrusions are the origin of at least two major subpopulations of prominin‐1‐containing extracellular membrane particles. Intriguingly, the release of these particles has been implicated in (neuro)epithelial cell differentiation.