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Mitochondrial potassium channels and reactive oxygen species
Author(s) -
Malinska Dominika,
Mirandola Sandra R.,
Kunz Wolfram S.
Publication year - 2010
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2010.01.013
Subject(s) - reactive oxygen species , potassium channel , mitochondrion , chemistry , mitochondrial ros , potassium , microbiology and biotechnology , potassium channel opener , atp sensitive potassium channel , oxygen , biochemistry , biology , biophysics , endocrinology , glibenclamide , organic chemistry , diabetes mellitus
Pretreatment of tissues with potassium channel openers (KCO's) has been observed to be cytoprotective in a broad variety of insults. This phenomenon has been proposed to be intimately linked to activation of mitochondrial potassium channels which apparently modulate the mitochondrial production of reactive oxygen species (ROS). This critical review summarizes literature findings about the mitochondrial production of ROS, the action of KCO's on mitochondrial ROS production and the putative link to the cytoprotective action of these drugs.