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Mitochondrial Ca 2+ channels: Great unknowns with important functions
Author(s) -
Malli Roland,
Graier Wolfgang F.
Publication year - 2010
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2010.01.010
Subject(s) - chemistry , biophysics , physics , biology
Mitochondria process local and global Ca 2+ signals. Thereby the spatiotemporal patterns of mitochondrial Ca 2+ signals determine whether the metabolism of these organelles is adjusted or cell death is executed. Mitochondrial Ca 2+ channels of the inner mitochondrial membrane (IMM) actually implement mitochondrial uptake from cytosolic Ca 2+ rises. Despite great efforts in the past, the identity of mitochondrial Ca 2+ channels is still elusive. Numerous studies aimed to characterize mitochondrial Ca 2+ uniport channels and provided a detailed profile of these great unknowns with important functions. This mini‐review revisits previous research on the mechanisms of mitochondrial Ca 2+ uptake and aligns them with most recent findings.