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Flavones suppress type I IL‐4 receptor signaling by down‐regulating the expression of common gamma chain
Author(s) -
Yamashita Shuya,
Yamashita Tatsunori,
Yamada Koji,
Tachibana Hirofumi
Publication year - 2010
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2009.12.044
Subject(s) - flavones , signal transduction , phosphorylation , chemistry , stat protein , receptor , stat , immunoglobulin e , microbiology and biotechnology , biology , biochemistry , antibody , stat3 , immunology , chromatography
Immunoglobulin E (IgE) production is induced by interleukin (IL)‐4 signaling mediated by type I IL‐4 receptor (IL‐4R) in B cells. We found that flavones inhibited IL‐4‐induced ε germline transcription which is essential for IgE class switching, and the phosphorylation of signal transducer and activator of transcription 6, janus kinase 3, and IL‐4Rα, whereas IL‐4 signaling mediated through type II IL‐4R was unaffected by flavones. Furthermore, flavones reduced the expression of common gamma chain, a characteristic constituent subunit of type I IL‐4R, suggesting that flavones suppress type I IL‐4R signaling.