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The urokinase receptor: Focused cell surface proteolysis, cell adhesion and signaling
Author(s) -
Blasi Francesco,
Sidenius Nicolai
Publication year - 2010
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2009.12.039
Subject(s) - urokinase receptor , microbiology and biotechnology , chemistry , proteolysis , urokinase , serine protease , receptor , plasmin , cell adhesion , extracellular matrix , cell migration , supar , plasminogen activator , proteases , protease , cancer research , cell , biology , biochemistry , enzyme , endocrinology , genetics
uPAR is highly expressed during tissue reorganization, inflammation, and in virtually all human cancers. Since its discovery, in vitro and in vivo models, as well as retrospective clinical studies have shown that over‐expression of components of the uPA/uPAR‐system correlates with increased proliferation, migration, and invasion affecting the malignant phenotype of cancer. uPAR regulates the cells–extracellular matrix interactions promoting its degradation and turnover through the plasminogen activation cascade.