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Interaction of mitochondrial potassium channels with the permeability transition pore
Author(s) -
Cheng Yu,
Debska-Vielhaber Grazyna,
Siemen Detlef
Publication year - 2010
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2009.12.038
Subject(s) - potassium channel , biophysics , potassium , mitochondrion , chemistry , permeability (electromagnetism) , membrane , membrane potential , inner mitochondrial membrane , ion channel , sk channel , mitochondrial permeability transition pore , microbiology and biotechnology , biochemistry , biology , apoptosis , receptor , organic chemistry , programmed cell death
Three types of potassium channels cooperate with the permeability transition pore (PTP) in the inner mitochondrial membranes of various tissues, mtK (ATP) , mtBK, and mtKv1.3. While the latter two share similarities with their plasma membrane counterparts, mtK (ATP) exhibits considerable differences with the plasma membrane K (ATP) ‐channel. One important function seems to be suppression of release of proapototic substances from mitochondria through the PTP. Open potassium channels tend to keep the PTP closed thus acting as antiapoptotic. Nevertheless, in their mode of action there are considerable differences among them. This review introduces three K + ‐channels and the PTP, and discusses known facts about their interaction.