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Properties of the intracellular transient receptor potential (TRP) channel in yeast, Yvc1
Author(s) -
Chang Yiming,
Schlenstedt Gabriel,
Flockerzi Veit,
Beck Andreas
Publication year - 2010
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2009.12.035
Subject(s) - yeast , transient receptor potential channel , chlamydomonas reinhardtii , transmembrane protein , peptide sequence , transmembrane domain , biology , ion channel , chlamydomonas , saccharomyces cerevisiae , protein primary structure , biochemistry , trpc1 , sequence (biology) , gene , amino acid , microbiology and biotechnology , genetics , receptor , mutant
Transient receptor potential (TRP) channels are found among mammals, flies, worms, ciliates, Chlamydomonas , and yeast but are absent in plants. These channels are believed to be tetramers of proteins containing six transmembrane domains (TMs). Their primary structures are diverse with sequence similarities only in some short amino acid sequence motifs mainly within sequences covering TM5, TM6, and adjacent domains. In the yeast genome, there is one gene encoding a TRP‐like sequence. This protein forms an ion channel in the vacuolar membrane and is therefore called Yvc1 for yeast vacuolar conductance 1. In the following we summarize its prominent features.