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Divalent metal‐dependent regulation of hepcidin expression by MTF‐1
Author(s) -
Balesaria Sara,
Ramesh Bala,
McArdle Harry,
Bayele Henry K.,
Srai Surjit K.S.
Publication year - 2010
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2009.12.023
Subject(s) - hepcidin , divalent , transcription factor , chemistry , dmt1 , peptide , transcription (linguistics) , zinc finger , metal , inflammation , microbiology and biotechnology , biochemistry , biology , transporter , gene , immunology , linguistics , philosophy , organic chemistry
Hepcidin is a small acute phase peptide that regulates iron absorption. It is induced by inflammation and infection, but is repressed by anaemia and hypoxia. Here we further reveal that hepcidin transcription also involves interactions between functional metal response elements (MREs) in its promoter, and the MRE‐binding transcription factor‐1. Analysis of hepcidin mRNA and protein levels in hepatoma cells suggests that its expression may be regulated by divalent metal ions, with zinc inducing maximal effects on hepcidin levels. These data suggest that this peptide may be a pleiotropic sensor of divalent metals, some of which are xenobiotic environmental toxins.