Premium
Curcumin inhibits hepatitis C virus replication via suppressing the Akt‐SREBP‐1 pathway
Author(s) -
Kim KyeongJin,
Kim Kook Hwan,
Kim Hye Young,
Cho Hyun Kook,
Sakamoto Naoya,
Cheong JaeHun
Publication year - 2010
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2009.12.019
Subject(s) - curcumin , virology , hepatitis c virus , viral replication , virus , protein kinase b , biology , in vitro , chemistry , apoptosis , pharmacology , biochemistry
A polyphenolic compound from the curry spice turmeric, curcumin, is known to show anti‐viral activity against the influenza virus, adenovirus, coxsackievirus, and the human immunodeficiency virus. However, it remains to be determined whether curcumin can inhibit the replication of hepatitis C virus (HCV). In this study, we showed that curcumin decreases HCV gene expression via suppression of the Akt‐SREBP‐1 activation, not by NF‐κB pathway. The combination of curcumin and IFNα exerted profound inhibitory effects on HCV replication. Collectively, our results indicate that curcumin can suppress HCV replication in vitro and may be potentially useful as novel anti‐HCV reagents.