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Lactobacillus strains induce TRAIL production and facilitate natural killer activity against cancer cells
Author(s) -
Horinaka Mano,
Yoshida Tatsushi,
Kishi Atsuko,
Akatani Kaoru,
Yasuda Takashi,
Kouhara Junji,
Wakada Miki,
Sakai Toshiyuki
Publication year - 2010
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2009.12.004
Subject(s) - peripheral blood mononuclear cell , tumor necrosis factor alpha , cytokine , apoptosis , antibody , cancer cell , cancer research , immunology , endogeny , cancer , biology , chemistry , in vitro , biochemistry , genetics
Tumor necrosis factor‐related apoptosis‐inducing ligand (TRAIL) is an endogenous cytokine that induces apoptosis in malignant tumor cells. Here, we show for the first time that lactobacilli induce TRAIL production in human peripheral blood mononuclear cells (PBMC). Treatment with lactobacilli induced TRAIL on the cell surface of PBMC and in culture medium. The TRAIL production induced by lactobacilli partially depends on IFN‐α and IFN‐γ. Lactobacilli treatment facilitated NK activity of PBMC against prostate cancer cells. Moreover, TRAIL neutralization antibody efficiently prevented the NK activity. Our results indicate that lactobacilli facilitate NK activity through TRAIL production, and raise the possibility of a new TRAIL‐based strategy against malignant tumors.