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Gallic acid induces GLUT4 translocation and glucose uptake activity in 3T3‐L1 cells
Author(s) -
Vishnu Prasad C.N.,
Anjana T.,
Banerji Asoke,
Gopalakrishnapillai Anilkumar
Publication year - 2010
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2009.11.092
Subject(s) - glut4 , glucose transporter , glucose uptake , chromosomal translocation , wortmannin , biochemistry , chemistry , intracellular , gallic acid , microbiology and biotechnology , protein kinase b , phosphorylation , biology , insulin , endocrinology , gene , antioxidant
GLUT4, a 12 transmembrane protein, plays a major role in insulin mediated glucose transport in muscle and adipocytes. For glucose transport, the GLUT4 protein needs to be translocated to the plasma membrane from the intracellular pool and it is possible that certain compounds may be able to enhance this process. In the present work, we have shown that gallic acid can increase GLUT4 translocation and glucose uptake activity in an Akt‐independent but wortmannin‐sensitive manner. Further analysis suggested the role of atypical protein kinase Cζ/λ in gallic acid mediated GLUT4 translocation and glucose uptake.