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Adrenomedullin protects against hypoxia/reoxygenation‐induced cell death by suppression of reactive oxygen species via thiol redox systems
Author(s) -
Kim Su-Mi,
Kim Jee-Youn,
Lee Sun,
Park Jae-Hoon
Publication year - 2010
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2009.11.063
Subject(s) - reactive oxygen species , adrenomedullin , glutathione , thioredoxin , chemistry , thioredoxin reductase , programmed cell death , hypoxia (environmental) , glutathione reductase , oxidative stress , thiol , glutathione peroxidase , biochemistry , oxygen , microbiology and biotechnology , apoptosis , biology , enzyme , receptor , organic chemistry
Adrenomedullin (ADM) functions as a survival factor against hypoxic cell death. However, molecular mechanisms underlying the cell survival pathway remain largely unknown. In this report, we showed that ADM suppressed reactive oxygen species (ROS) increase by inhibiting reduction of glutathione (GSH) level in hypoxia/reoxygenation (H/R) injury, and increased the activities of glutathione peroxidase and reductase. In addition, ADM maintained total and active reduced thioredoxin (Trx) levels against H/R. We also found that ADM blocked nuclear translocation of Trx induced by H/R. The results of the present study show that ADM regulates cellular ROS levels via the GSH and Trx system.