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Rab35 – A vesicular traffic‐regulating small GTPase with actin modulating roles
Author(s) -
Chua Christelle En Lin,
Lim Yi Shan,
Tang Bor Luen
Publication year - 2010
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2009.11.051
Subject(s) - rab , microbiology and biotechnology , gtpase , small gtpase , cytokinesis , actin , vesicular transport protein , cdc42 , endosome , biology , gtpase activating protein , guanine nucleotide exchange factor , actin cytoskeleton , cytoskeleton , chemistry , g protein , vesicle , signal transduction , cell , biochemistry , membrane , cell division , intracellular
The Rab family of GTPases are regulators of eukaryotic vesicular membrane traffic, while modulation of actin dynamics is a function conventionally associated with the Rho family of GTPases. Rab35 is a Rab protein with both plasma membrane and endosomal localization, and has been implicated in diverse processes that include T‐cell receptor recycling, oocyte yolk protein recycling and cytokinesis. Rab35 regulates neurite outgrowth in neuronal‐like cells, and can induce protrusions even in typically non‐adherent Jurkat T‐cells. Recent evidence indicates that Rab35's activity, particularly the ability to mediate protrusive outgrowths, is due to its direct influence on actin dynamics. This can occur via activation of the Rho family of GTPases, or through the engagement of its effector fascin, an actin bundling protein.