Premium
Fine tuning of cell functions through remodeling of glycosphingolipids by plasma membrane‐associated glycohydrolases
Author(s) -
Sonnino Sandro,
Aureli Massimo,
Loberto Nicoletta,
Chigorno Vanna,
Prinetti Alessandro
Publication year - 2010
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2009.11.020
Subject(s) - sphingolipid , endoplasmic reticulum , glycosphingolipid , membrane , catabolism , golgi apparatus , microbiology and biotechnology , chemistry , biochemistry , cell membrane , enzyme , biology
The plasma membrane (PM) sphingolipid composition is the result of a series of well‐known metabolic pathways comprising neobiosynthesis in the endoplasmic reticulum and in the Golgi apparatus followed by vesicular delivery to the plasma membrane, membrane turnover with final catabolism in lysosomes, and shedding of membrane components. In addition to this, the head group of PM sphingolipids can be opportunely modified by the action of PM associated hydrolases and transferases. The number of enzymes for glycosphingolipid metabolism that have been shown to be associated with the plasma membrane and the information on their properties are growing very rapidly. In this review, we will focus on the possible role and on the involvement of the plasma membrane‐associated glycohydrolases in modulating cell functions.