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Eukaryotic and archaeal translation initiation factor 2: A heterotrimeric tRNA carrier
Author(s) -
Schmitt Emmanuelle,
Naveau Marie,
Mechulam Yves
Publication year - 2010
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2009.11.002
Subject(s) - heterotrimeric g protein , initiation factor , eukaryotic translation , eif2 , guanine nucleotide exchange factor , eukaryotic initiation factor , translation (biology) , eif4a1 , biology , eukaryotic translation initiation factor 4 gamma , microbiology and biotechnology , genetics , computational biology , gtpase , chemistry , messenger rna , gene , g protein , signal transduction
Eukaryotic/archaeal translation initiation factor 2 (e/aIF2) is a heterotrimeric GTPase that plays a key role in selection of the correct start codon on messenger RNA. This review integrates structural and functional data to discuss the involvement of the three subunits in initiator tRNA binding. A possible role of the peripheral subunits in modulating the guanine nucleotide cycle on the core subunit is also addressed.