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Multiple routes of protein transport from endosomes to the trans Golgi network
Author(s) -
Pfeffer Suzanne R.
Publication year - 2009
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2009.10.075
Subject(s) - endosome , golgi apparatus , vesicular transport proteins , microbiology and biotechnology , transport protein , chemistry , mannose , receptor , biology , biochemistry , endoplasmic reticulum , vacuolar protein sorting
Proteins use multiple routes for transport from endosomes to the Golgi complex. Shiga and cholera toxins and TGN38/46 are routed from early and recycling endosomes, while mannose 6‐phosphate receptors are routed from late endosomes. The identification of distinct molecular requirements for each of these pathways makes it clear that mammalian cells have evolved more complex targeting mechanisms and routes than previously anticipated.