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Pancreatic cancer cells activate CCL5 expression in mesenchymal stromal cells through the insulin‐like growth factor‐I pathway
Author(s) -
Makinoshima Hideki,
Dezawa Mari
Publication year - 2009
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2009.10.061
Subject(s) - mesenchymal stem cell , ccl5 , stromal cell , cancer research , pancreatic cancer , chemokine , cancer cell , metastasis , microbiology and biotechnology , biology , growth factor , chemistry , cancer , immunology , receptor , inflammation , t cell , il 2 receptor , biochemistry , immune system , genetics
Mesenchymal stromal cells (MSCs) have a critical role in cancer progression and metastasis. Despite extensive studies of the physiological responses in cancer cells, the molecular mechanisms regulating gene expression in MSCs by cancer cells remain undefined. Here we demonstrate that CC chemokine ligand 5 (CCL5) expression was increased in MSCs co‐cultured with pancreatic cancer cells (PCCs), and this activation was dependent on extracellular insulin‐like growth factor (IGF‐I). Moreover, CCL5 induction in MSCs was required for the activation of IGF‐I pathway in PCCs. These results reveal a link between the IGF‐I pathway in PCCs and CCL5 pathway in MSCs through the interaction of those cells.