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The KDEL receptor: New functions for an old protein
Author(s) -
Capitani Mirco,
Sallese Michele
Publication year - 2009
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2009.10.053
Subject(s) - kdel , golgi apparatus , endoplasmic reticulum , microbiology and biotechnology , receptor , chaperone (clinical) , biology , transmembrane protein , chemistry , biochemistry , medicine , pathology
The KDEL receptor is a seven‐transmembrane‐domain protein that was first described about 20 years ago. Its well‐known function is to retrotransport chaperones from the Golgi complex to the endoplasmic reticulum. Recent studies, however, have suggested that the KDEL receptor has additional functions. Indeed, we have demonstrated that chaperone‐bound KDEL receptor triggers the activation of Src family kinases on the Golgi complex. This activity is essential in the regulation of Golgi‐to‐plasma membrane transport. However, the identification of different KDEL receptor interactors that are inconsistent with these established functions opens the possibility of further receptor activities.