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A novel neural‐specific BMP antagonist, Brorin‐like, of the Chordin family
Author(s) -
Miwa Hiroyuki,
Miyake Ayumi,
Kouta Yuya,
Shimada Akihiko,
Yamashita Yuki,
Nakayama Yoshiaki,
Yamauchi Hajime,
Konishi Morichika,
Itoh Nobuyuki
Publication year - 2009
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2009.10.044
Subject(s) - chordin , neurogenesis , zebrafish , noggin , neural development , bone morphogenetic protein , microbiology and biotechnology , biology , embryonic stem cell , chemistry , gene , biochemistry
We identified a gene encoding a novel secreted protein in mice, humans, and zebrafish. As the protein of 222 amino acids is similar to Brorin, a secreted BMP antagonist, which is a member of the Chordin family, we named it Brorin‐like. Recombinant Brorin‐like protein weakly but significantly inhibited the activity of BMP in mouse preosteoblastic cells and promoted neurogenesis in mouse neural precursor cells. Brorin‐like was predominantly expressed in the adult brain and embryonic neural tissues. The inhibition of Brorin‐like functions in zebrafish resulted in the impairment of neural development. Brorin‐like potentially plays roles in neural development and functions.