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ER exit sites – Localization and control of COPII vesicle formation
Author(s) -
Budnik Annika,
Stephens David J.
Publication year - 2009
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2009.10.038
Subject(s) - copii , endoplasmic reticulum , golgi apparatus , microbiology and biotechnology , vesicle , copi , secretory pathway , budding , function (biology) , biology , secretion , vesicular transport proteins , chemistry , intracellular , biochemistry , membrane , endosome , vacuolar protein sorting
The first membrane trafficking step in the biosynthetic secretory pathway, the export of proteins and lipids from the endoplasmic reticulum (ER), is mediated by COPII‐coated vesicles. In mammalian cells, COPII vesicle budding occurs at specialized sites on the ER, the so‐called transitional ER (tER). Here, we discuss aspects of the formation and maintenance of these sites, the mechanisms by which cargo becomes segregated within them, and the propagation of ER exit sites (ERES) during cell division. All of these features are inherently linked to the formation, maintenance and function of the Golgi apparatus underlining the importance of ERES to Golgi function and more widely in terms of intracellular organization and cellular function.