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Modeling membrane shaping by proteins: Focus on EHD2 and N‐BAR domains
Author(s) -
Campelo Felix,
Fabrikant Gur,
McMahon Harvey T.,
Kozlov Michael M.
Publication year - 2010
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2009.10.023
Subject(s) - membrane curvature , membrane , membrane protein , membrane biophysics , bending , biophysics , microbiology and biotechnology , chemistry , biology , engineering , structural engineering , biochemistry , lipid bilayer
Cellular membranes are highly dynamic, undergoing both persistent and dynamic shape changes driven by specialized proteins. The observed membrane shaping can be simple deformations of existing shapes or membrane remodeling involving fission or fusion. Here we describe several mechanistic principles by which membrane shaping proteins act. We especially consider models for membrane bending and fission by EHD2 proteins and membrane bending by N‐BAR domains. There are major challenges ahead to understand the general principles by which diverse membrane bending proteins act and to understand how some proteins appear to span multiple modes of action from driving curvature to inducing membrane remodeling.