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Role of sestrin2 in peroxide signaling in macrophages
Author(s) -
Essler Silke,
Dehne Nathalie,
Brüne Bernhard
Publication year - 2009
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2009.10.017
Subject(s) - glutaredoxin , thioredoxin , reactive oxygen species , microbiology and biotechnology , oxidative stress , nitric oxide , thioredoxin reductase , cell signaling , biochemistry , chemistry , signal transduction , biology , organic chemistry
Reactive oxygen species not only serve as signaling molecules, they also contribute to oxidative stress and cell damage. The thioredoxin and glutaredoxin systems form along with peroxiredoxins a precisely regulated defense system to maintain the cellular redox homeostasis. There is evidence that nitric oxide (NO) protects cells from oxidative stress by preventing inactivation of peroxiredoxins by sulfinylation. Here we demonstrate that NO and hypoxia upregulate Sestrin2 by HIF‐1‐dependent and additional mechanisms and that Sestrin2 contributes to preventing peroxiredoxins from sulfinylation. We conclude that Sestrin2 plays a role in peroxide defense as a reductase for peroxiredoxins.